Tranexamic Acid to Prevent Obstetrical Hemorrhage after Cesarean Delivery

N Engl J Med, April 13, 2023

Luis D. Pacheco, M.D., Rebecca G. Clifton, Ph.D., George R. Saade, M.D., Steven J. Weiner, M.S., Samuel Parry, M.D., John M. Thorp, Jr., M.D., Monica Longo, M.D., Ph.D., Ashley Salazar, R.N., M.S.N., W.H.N.P., Wendy Dalton, R.N., Alan T.N. Tita, M.D., Ph.D., Cynthia Gyamfi-Bannerman, M.D., Suneet P. Chauhan, M.D., et al., for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network*

April 13, 2023
N Engl J Med 2023; 388:1365-1375
DOI: 10.1056/NEJMoa2207419

Background: Prophylactic use of tranexamic acid at the time of cesarean delivery has been shown to decrease the calculated blood loss, but the effect on the need for blood transfusions is unclear.